Endocrine Abstracts

A 55-year-old gentleman was referred to surgeons for screening colonoscopy in view of family history of bowel cancer. His mother, maternal aunt and two cousins had history of bowel cancer. When seen by the surgeons, he gave 4-month history of intermittent abdominal bloating and rectal bleeding. His past medical history included a recent diagnosis of hypertension, a chronic history of facial neuralgia and history of excision of numerous facial skin tags. He was on amlodipine 5 ...

A 45-year-old male to female transsexual presented with poor female fat distribution. She had been treated with oestrogen for 13 years, initially as ethinyl oestradiol to a maximum dose of 150 ug/day, presently taking 100 mcg with GNRH analogue. On this regimen she had B cup breast development but underwent breast augmentation surgery and still suffered from low self-esteem. She was dissatisfied with her body image because she perceived a male body fat distribution. Her initia...

Introduction: • The incidence of primary hyperparathyroidism (PHPT) in Scotland is approximately 3.5/100 000 per year.• The incidence is probably on the rise due to increase in ‘routine biochemical testing’• Some patients tend to undergo surgery, while others are conservatively treated and most followed up for a short period before discharge from follow up.Aims: • Determine if ri...

Introduction: Short synacthen tests (SST) are widely performed as a screening test in patients with suspected hypoadrenalism. However, the timing of sampling and interpretation of cortisol levels remain a matter of controversy. Though known to be inferior to 30 min cortisol levels, some centres continue to analyse 60 min values (along with 30 min levels) to avoid resource-intensive tests like insulin stress tests and glucagon stimulation tests.Objective:...

Introduction. Adiponectin is a novel circulating adipocyte derived protein, whose plasma concentrations paradoxically decrease with increasing fat mass. Adiponectin has been shown to improve both glucose and lipid metabolism, and circulating concentrations are inversely correlated with insulin resistance. The factors regulating adiponectin expression and secretion are poorly understood. No study has previously examined the acute post-prandial regulation of adiponectin s...

INTRODUCTION: Although thyrotoxicosis involving the musculoskeletal system is well described, classically presenting with proximal myopathy, arthralgia and osteopenia, an acute synovio-arthritis is extremely rare. There are only two published case reports, which have features distinct from Rheumatoid, Sjogren's and Psoriatic arthropathy.CASE REPORT: A 21-year-old lady presented with a 2-month history of symptoms and signs consistent with thyrotoxicosis....

Background: numerous studies using a variety of quality of life (QOL) measures have shown multiple impairments in adults with growth hormone deficiency (GHD) compared to control subjects. There have been few studies however of QOL in a treated GHD population compared with healthy controls.Method: 120 adults with treated GHD ( >1 year) were given the following QOL questionnaires at annual review: SF36, Nottingham Health Profile, Disease Impact, Life F...

Background: We previously demonstrated that elderly patients with GHD have increased and young GHD patients have reduced cardiac sympathovagal balance. Therefore we decided to investigate whether the relationship between age and cardiac sympathovagal balance is altered in GHD compared to healthy controls.Method: HRV, which indirectly measures cardiac sympathovagal balance, was measured in 22 untreated GHD patients (13 F; mean age 47.4 yrs; range 19-73 y...

Little is known on the impact of acute COVID-19 infection on causation of diabetes. We report on a 36 years old man from Nigeria who presented with diabetic ketoacidosis (DKA) with typical osmotic symptoms of polyuria and polydipsia, fatigue and weight loss over 2 weeks. He tested positive for SARS-COV2 by PCR. The initial laboratory results: Random glucose 30.6 mmol/l, capillary blood ketones 7.4 mmol/l, pH 7.22, bicarbonate 7.5 mmol/l. Despite insulinopaenic state, at presen...